Bruker Announces Successful Installation of a 1.2 GHz NMR at the Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin
The Avance® 1.2 GHz NMR system will enable advanced studies of biomolecular structures and function in structural biology, pharmacology, and cellular biology
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New 1.2 GHz Avance® NMR system at Forschungsinstitut für Molekulare Pharmakologie (FMP) in
Ultra-high field NMR is a vital tool in pharmacology research, providing unique insights into molecular dynamics and structural rearrangements related to drug-target binding, protein interactions, and macromolecular structure refinements and rearrangements. Intrinsically disordered proteins (IDPs) play key roles in cell biology, such as IDPs implicated in cancer and infectious diseases. IDPs can be studied in depth using GHz-class NMR, by taking advantage of increased resolution of 1.2 GHz NMR. Researchers can gain an understanding of the conformational dynamics and function of IDPs to unlock the secrets of these important proteins and their role in diseases. This makes 1.2 GHz NMR a powerful tool for advancing our understanding of cellular and disease biology, and the development of therapies.
The Leibniz Forschungsinstitut für Molekulare Pharmakologie is a respected research institute committed to advancing the field of molecular pharmacology through groundbreaking research and innovation. Since 1995, the institute has integrated eleven NMR systems, including the recently installed 1.2 GHz AVANCE® NMR spectrometer. Dr.
Professor Hartmut Oschkinat, whose scientific work and persistence were essential for the realization of the 1.2 GHz system, added: “With the 1.2 GHz instrument, we are entering a new realm of unimagined possibilities, thanks to the unwavering commitment of our partners at Bruker to drive innovation in NMR."
The new device will serve FMP groups that are dedicated to advancing the molecular basis of pharmacological therapies by characterizing novel active compounds and mechanisms of action prior to drug development. Professor
The Integrated Structural Dynamics team, led by Junior Group Leader Dr.
Dr.
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