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About the company
Spyre Therapeutics, Inc. is a biotechnology company. The Company is engaged in creating inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations and precision medicine approaches. Its pipeline includes investigational extended half-life antibodies targeting a4B7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, and SPY230. It has nominated development candidates for SPY001 and SPY002. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4B7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a discovery-stage program focused on designing antibodies to bind to Interleukin 23 (IL-23).
- Revenue in USD (TTM)0.00
- Net income in USD-185.98m
- Incorporated2013
- Employees50.00
- LocationSpyre Therapeutics Inc221 Crescent Street, Suite 105WALTHAM 02453United StatesUSA
- Phone+1 (617) 651-5940
- Fax+1 (302) 636-5454
- Websitehttps://spyre.com/
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Peer analysis
Key Information
- Key Information
- Stock Performance
- Per Share Data
- Efficiency
- Management Effectiveness
- Profitability
- Financial Strength
- Growth Rates
| Company | Revenue (TTM) | Net income (TTM) | Market cap | Employees | Price/earnings (TTM) | Price/book value (MRQ) | Price/cash flow (TTM) | Price/sales (TTM) | EPS (excl. extraordinary items, TTM) | EPS (incl. extraordinary items, TTM) | Revenue per share (TTM) | Book value per share (MRQ) | Asset turnover (TTM) | Inventory turnover (TTM) | Receivables turnover (TTM) | Revenues per employee (TTM) | Return on avg assets (TTM) | Return on avg assets (5 yr avg) | Return on investment (TTM) | Return on investment (5 yr avg) | Gross margin (TTM) | Gross margin (5 yr avg) | Net profit margin (TTM) | Net Profit margin (5 yr avg) | Quick ratio (MRQ) | Interest coverage (TTM) | Total debt to capital (MRQ) | Payout ratio (5 yr avg) | Revenue (YOY change %) | Revenue (5 yr growth rate) | Net income (YOY change %) | Net income (5 yr growth rate) | Capital expenditure (5 yr growth rate) | Dividend (5 yr growth rate) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Syndax Pharmaceuticals Inc | 16.00m | -297.06m | 1.86bn | 112.00 | -- | 5.09 | -- | 116.35 | -3.63 | -3.63 | 0.1949 | 4.28 | 0.0388 | -- | 3.60 | 142,857.10 | -72.01 | -27.90 | -81.78 | -30.15 | -- | -- | -1,856.64 | -324.34 | -- | -- | 0.00003 | -- | -- | -- | -40.19 | -- | -- | -- |
| Arvinas Inc | 161.10m | -308.60m | 1.86bn | 445.00 | -- | 3.18 | -- | 11.58 | -4.79 | -4.79 | 2.38 | 8.53 | 0.1448 | -- | 14.01 | 362,022.50 | -27.73 | -22.01 | -37.81 | -26.47 | -- | -- | -191.56 | -316.55 | -- | -- | 0.001 | -- | -40.26 | 40.53 | -30.02 | -- | 0.4852 | -- |
| Viridian Therapeutics Inc | 288.00k | -228.06m | 1.92bn | 96.00 | -- | 4.89 | -- | 6,682.95 | -4.25 | -4.25 | 0.0053 | 8.29 | 0.0006 | -- | 5.65 | 3,063.83 | -48.67 | -55.59 | -52.32 | -60.32 | -- | -- | -79,185.77 | -5,678.12 | -- | -- | 0.0372 | -- | -82.28 | -48.16 | -83.05 | -- | 15.08 | -- |
| Disc Medicine Inc | 0.00 | -91.00m | 1.93bn | 74.00 | -- | 3.95 | -- | -- | -3.66 | -3.66 | 0.00 | 16.45 | 0.00 | -- | -- | 0.00 | -20.35 | -- | -21.06 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -63.22 | -- | -- | -- |
| Nurix Therapeutics Inc | 56.42m | -176.98m | 1.94bn | 284.00 | -- | 4.87 | -- | 34.32 | -2.91 | -2.91 | 0.9222 | 5.62 | 0.1373 | -- | -- | 198,676.10 | -43.07 | -33.01 | -52.51 | -39.66 | -- | -- | -313.65 | -260.65 | -- | -- | 0.00 | -- | 99.31 | 15.50 | 20.19 | -- | 39.42 | -- |
| Mirum Pharmaceuticals Inc | 264.38m | -109.16m | 2.00bn | 294.00 | -- | 8.73 | -- | 7.58 | -2.40 | -2.40 | 5.81 | 4.81 | 0.4788 | 5.06 | 5.52 | 1,001,424.00 | -19.77 | -38.93 | -23.38 | -44.88 | 72.27 | -- | -41.29 | -190.71 | 3.09 | -- | 0.573 | -- | 141.85 | -- | -20.45 | -- | 21.81 | -- |
| Spyre Therapeutics Inc | 0.00 | -185.98m | 2.01bn | 50.00 | -- | 9.20 | -- | -- | -15.42 | -15.42 | 0.00 | 7.37 | 0.00 | -- | -- | 0.00 | -54.73 | -101.87 | -87.47 | -118.83 | -- | -- | -- | -2,949.59 | -- | -- | 0.00 | -- | -61.96 | -25.61 | -304.21 | -- | -- | -- |
| MannKind Corp | 248.37m | 11.74m | 2.02bn | 414.00 | 204.77 | -- | 116.64 | 8.13 | 0.0359 | 0.0359 | 0.834 | -0.8226 | 0.656 | 2.85 | 9.71 | 599,937.20 | 3.10 | -26.07 | 4.05 | -37.80 | 71.29 | 59.68 | 4.73 | -57.61 | 3.76 | 1.86 | 1.89 | -- | 99.42 | 48.17 | 86.34 | -- | 160.47 | -- |
| Recursion Pharmaceuticals Inc | 65.18m | -377.75m | 2.04bn | 500.00 | -- | 3.87 | -- | 31.22 | -1.53 | -1.53 | 0.2631 | 1.83 | 0.096 | -- | 24.06 | 130,368.00 | -55.66 | -- | -65.45 | -- | 35.07 | -- | -579.51 | -- | -- | -- | 0.0519 | -- | 11.88 | -- | -36.99 | -- | -- | -- |
| Fortrea Holdings Inc | 2.88bn | -228.20m | 2.11bn | 16.00k | -- | 1.44 | -- | 0.732 | -2.56 | -3.23 | 32.30 | 16.33 | 0.7262 | -- | 3.48 | 159,794.40 | -5.76 | -- | -7.11 | -- | 17.17 | -- | -7.93 | -- | -- | -0.3374 | 0.4348 | -- | 0.4167 | -- | -101.76 | -- | -- | -- |
| Neumora Therapeutics Inc | 0.00 | -274.18m | 2.17bn | 108.00 | -- | 5.68 | -- | -- | -1.66 | -1.66 | 0.00 | 2.38 | 0.00 | -- | -- | 0.00 | -71.73 | -- | -76.67 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -80.23 | -- | -- | -- |
| Structure Therapeutics Inc (ADR) | 0.00 | -100.44m | 2.17bn | 136.00 | -- | 2.36 | -- | -- | -2.24 | -2.24 | 0.00 | 16.10 | 0.00 | -- | -- | 0.00 | -17.07 | -- | -17.64 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -69.62 | -- | -- | -- |
| Azenta Inc | 658.62m | -156.38m | 2.19bn | 3.30k | -- | 1.13 | -- | 3.33 | -2.82 | -2.81 | 11.73 | 39.50 | 0.2443 | 3.08 | 3.49 | 188,176.30 | -5.80 | -0.5934 | -6.27 | -0.6725 | 39.78 | 43.08 | -23.74 | -2.17 | 4.21 | -- | 0.00 | -- | 19.73 | 1.04 | -14.15 | -- | 25.26 | -- |
Data as of Nov 08 2024. Currency figures normalised to Spyre Therapeutics Inc's reporting currency: US Dollar USD
57.65%Per cent of shares held by top holders
| Holder | Shares | % Held |
|---|---|---|
| Fidelity Management & Research Co. LLCas of 30 Jun 2024 | 6.89m | 13.53% |
| Fairmount Funds Management LLCas of 30 Jun 2024 | 4.02m | 7.89% |
| RTW Investments LPas of 30 Jun 2024 | 3.26m | 6.40% |
| Perceptive Advisors LLCas of 30 Jun 2024 | 3.03m | 5.95% |
| Braidwell LPas of 30 Jun 2024 | 2.51m | 4.94% |
| BlackRock Fund Advisorsas of 30 Jun 2024 | 2.19m | 4.31% |
| Commodore Capital LPas of 30 Jun 2024 | 1.99m | 3.90% |
| The Vanguard Group, Inc.as of 30 Jun 2024 | 1.87m | 3.66% |
| Avoro Capital Advisor LLCas of 30 Jun 2024 | 1.84m | 3.61% |
| Deep Track Capital LPas of 30 Jun 2024 | 1.76m | 3.45% |
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Data from 30 Jun 2024 - 30 Jun 2024Source: FactSet Research Systems Inc.
